Pifithrin-α 抑制剂，MDM-2/p53

产品描述：

一种p53抑制剂，抑制p53依赖性的p53应答基因转录。

本Pifithrin-α为Pifithrin-α• hydrobromide，简称Pftα，是一种常用的p53抑制剂。Pifithrin-α能可逆性地抑制p53依赖的基因转录激活，例如cyclin G, p21/waf1和mdm2；也可以抑制p53介导的细胞凋亡。本产品为进口分装，纯度大于98%。可以用于细胞培养，也可以用于动物实验。

产品特性：

CAS NO：63208-82-2

MW:367.30

MF:C16H18N2OS·HBr，

溶解性：可溶于DMSO或甲醇。溶于DMSO(20 mg/mL)

包装：5mg 25mg 100mg in glass bottle

Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.