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渥曼青霉素
| 英文名 | Wortmannin | CAS号 | 19545-26-7 |
| 产品编号 | FS1266 | 分子式 | C23H24O8 |
| 产品分类 | 生化试剂产品 | 分子量 | 428.431867599487 |
| 纯度 | ≥98%(HPLC) | 储存条件 | -20°C |
产品描述
一种PI3Ks和PLK1的特异性共价抑制剂。
Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K.
溶解性：溶于DMSO(86mg/mL)
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