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E-64
| 英文名 | E-64 | CAS号 | 66701-25-5 |
| 产品编号 | FS1018 | 分子式 | C15H27N5O5 |
| 产品分类 | 蛋白酶抑制剂 | 分子量 | 357.41 |
| 纯度 | ≥98%(HPLC) | 储存条件 | -20℃ |
产品描述：
一种非可逆的选择性的半胱氨酸蛋白酶(cysteine proteases)抑制剂,作用于cathepsins K、cathepsins S和cathepsins L，IC50分别为1.4nM、4.1nM和2.5nM。
E-64 is a broad spectrum cysteine proteinase and calpain activation inhibitor. E-64 has been reported to inhibit intracellular cathepsin B, cathepsin L, cathepsin H, Bax protease activity, and reduces oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP acitivity. Additionally, Prevotella intermedia studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S。
溶解性：溶于DMSO(≥22mg/mL)和水（36mg/mL）
包装：5mg 25mg 100mg in glass bottle
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