刀豆素A

产品简介

Concanamycin A (Folimycin; Antibiotic X 4357B) 是一种大环内酯类抗生素，是空泡状 H+-ATP 酶 (V-ATPase) 抑制剂。Concanamycin A 是一种溶酶体酸化抑制剂，可用于 T 细胞介导的炎症研究。

产品特性

CAS 号：80890-47-7

中文名称：刀豆素A；伴刀球霉素A

英文名称：Concanamycin A；Antibiotic X 4357B；Folimycin；X 4357B

Formula：C₄₆H₇₅NO₁₄

分子量：866.09

性状：White to off-white 白色固体

溶解性：溶于DMSO；甲醇

保存及运输条件：冻干粉-20°C避光保存至少2年有效，

储备液保存：-80°C, 6 months；-20°C, 1 month

体外研究：

Concanamycin A can come from S. diastatochromogenes 545, as a microbial metabolite with immunomodulatory activity.

Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while

CD8+ population in mice immunized is more sensitive.

Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production.

Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM).

体内研究：

Concanamycin A (15 mg/kg; i.v.; 0, 10 or 24 h prior to sacrifice) induced T cell-mediated hepatitis in mice.