GLUT inhibitor-1

产品简介

GLUT inhibitor-1 是一种有效且具有口服活性的葡萄糖转运蛋白抑制剂，靶向 GLUT1 和 GLUT3，IC50s 值分别为 242 nM 和 179 nM。GLUT inhibitor-1 具有研究癌症和自身免疫性疾病的潜力。

GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.

靶点活性：GLUT3:179 nM (IC50), GLUT1:242 nM (IC50)

体内活性：GLUT inhibitor-1 exhibits good oral pharmacokinetic parameters in mice and rats with oral Cmax values of 2525 and 1675 ng/mL, AUCs of 5890 and 6813 ng/mL, CLs of 40 and 37 mL/min/kg, Vdss of 1.70 and 4.51 L/Kg, t1/2s of 0.785 and 2.59h and Fs of 45.4% and 49.4%[1].

CAS No：2421141-40-2

分子量：549.67

分子式：C₃₂H₃₅N₇O₂

存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 90mg/mL (163.7mM), ultrasonic and warming and heat to 60°C